More Joint Support Than Ever Before!
Submitted by Life Extension

As you grow older, age-related stiffness and discomfort in the joints becomes a fact of life. Activities once routine become a challenge as limited mobility hampers your every move. You now have a more potent option to provide broad-spectrum support for aging joints. ArthroMax™ Advanced with UC-II® and AprèsFlex™ is a multi-nutrient formula based on the very latest data on natural support for joint health. The new ArthroMax™ formula provides more joint support than ever before, enhanced with two innovative, clinically validated ingredients: AprèsFlex™ and UC-II^®.

AprèsFlex™ represents a quantum leap forward in the delivery to aging joints of boswellia, long prized for its ability to help with inflammatory issues. It is a superior inhibitor of the enzyme 5-lipoxygenase or 5-LOX.

Excess activity of 5-LOX results in the accumulation of leukotriene B4, a proinflammatory compound that affects aging joints. Boswellia has been shown to bind directly to the 5-LOX enzyme, preventing it from facilitating production of pro-inflammatory leukotrienes.^46,47

AprèsFlex™ boswellia absorbs into the blood 52% better than previously available forms of boswellia, for superior effectiveness.

In addition to AprèsFlex™, this new ArthroMax™ contains a novel standardized chicken cartilage: UC-II^®. New data shows it helps with immune issues that can impact joint discomfort and ease of motion in aging individuals.

Taken orally, UC-II^® travels to the intestinal tract where it "introduces" the immune system to the same type of collagen molecules found in joint cartilage.

Not just any form of collagen will do. Normally, when chicken collagen is processed, its molecular shape is changed. It loses bioactivity and becomes denatured—which researchers found has no beneficial effect² on the immune system. Fortunately, a unique processing technique preserves the correct molecular shape of the collagen^3,4 and preserves its bioactivity⁵—producing a form known as undenatured collagen. The result of this innovative process is an undenatured chicken collagen called Bio-Collagen with Patented UC-II^®.

Scientific studies have found that UC-II^® reduced sensitive joint discomfort and eased joint function.^1,6-10 One double-blind, placebo-controlled study on patients found that UC-II^® provided relief by 33%, and decreased joint discomfort scores by a remarkable 40% in just 90 days.¹

References
1. Int J Med Sci. 2009;6(6):312-21.
2. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7443-6.
3. Int Immunopharmacol. 2011 Jan;11(1):12-8.
4. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
5. Immunol Rev. 2005;206:232-59.
6. J Vet Pharmacol Ther. 2005 Aug;28(4):385-90.
7. J Vet Pharmacol Ther. 2007 Jun;30(3):275-8.
8. Toxicol Mech Methods. 2007;17(4):189-96.
9. J Anim Physiol Anim Nutr (Berl). Epub 2011 May 30.
10. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84.
46. Wien Med Wochenschr. 2002;152(15-16):373-8.
47. J Ethnopharmacol. 2006 Sep 19;107(2):249-53.

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